The personalized, AI-assisted shot aims to train the immune system to attack tumors
Russian scientists have produced the first three test batches of a newly developed cancer vaccine at the Gamaleya Institute in Moscow, the center’s director, Alexander Gintsburg, has said. The breakthrough drug is an AI-assisted, mRNA-based vaccine designed to target malignant tumors using the patient’s own genetic data.
Reports on the readiness of the vaccine first emerged in September. Preclinical studies showed the drug could shrink tumors and slow their growth by 60-80%, depending on patient characteristics. The vaccine was initially expected to be used in patients with colorectal cancer.
“Most importantly, our leading oncology center – the Herzen Institute, headed by academician [Andrey] Kaprin – has obtained the full set of approvals needed to use the technology, from diagnostics and mRNA production to administering it to patients,” Gintsburg said. The vaccine batches remain experimental even though they have passed all quality checks, he stressed on Wednesday.
Unlike conventional vaccines that prevent infection and severe illness, mRNA cancer vaccines are not designed to stop disease transmission. Traditional vaccines are given to healthy people, while oncology vaccines are a new class of therapies used to treat advanced-stage cancer. They are described as “vaccines” because they act on the immune system, training it to recognize and destroy tumor cells.
The new vaccine is a personalized treatment built to target malignant tumors using the patient’s own genetic information. Developed with the help of artificial intelligence, the mRNA platform allows each dose to be tailored to an individual’s cancer profile, potentially offering a more precise and effective therapy.
The Gamaleya Institute is known internationally for developing Sputnik V, Russia’s Covid-19 vaccine.
Earlier, Russia began trials of a drug based on a genetically modified oncolytic smallpox virus for the treatment of brain cancer, a process expected to take around two years.
Last month, the Health Ministry also authorized the use of two cancer vaccines: NeoOncoVak, a therapeutic mRNA-based vaccine for melanoma, and Oncopept, a peptide vaccine for malignant tumors. Both are made individually for patients using genetic analysis of the tumor and other biomaterials, and have narrowly targeted therapeutic indications.
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